The aforementioned factors together are enabling growth in Europe.The Induced Pluripotent Stem Cells Market report examines competitive scenario by analyzing key players in the market. In adult cardiomyocytes (CMs), the type 2 ryanodine receptor (RYR2) is an indispensable Ca2+ release channel that ensures the integrity of excitation-contraction coupling, which is fundamental for every heartbeat.
By this process, they identified four factors, Oct4, Sox2, cMyc, and Klf4, which were each necessary and together sufficient to generate ESC-like colonies under selection for reactivation of Fbx15.
Chemical compounds, such as valproic acid, sodium butyrate, and histone deacetylase inhibitors, have been shown to enhance iPSC generation.In mouse iPSCs, pluripotency can be confirmed by the capacity to contribute to chimeras after blastocyst injection. Using a guinea pig model, Shiba et alIt was reported that transplanted human PSC–derived cardiac myocytes can engraft and form myocardium in rodents.To overcome the poor survival of transplanted cells, sheet- or patch-form cardiac myocytes and aggregates of cardiac myocytes have been used.Building on murine models, larger animal models have been reported more recently. organization.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)Establishment in culture of pluripotential cells from mouse embryos.Embryonic stem cell lines derived from human blastocysts.Viable offspring derived from fetal and adult mammalian cells.Expression of a single transfected cDNA converts fibroblasts to myoblasts.Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.Generation of germline-competent induced pluripotent stem cells.In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.Induction of pluripotent stem cells from adult human fibroblasts by defined factors.Induced pluripotent stem cell lines derived from human somatic cells.Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells.Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.Promotion of direct reprogramming by transformation-deficient Myc.A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells.Induced pluripotent stem cells generated without viral integration.Generation of mouse induced pluripotent stem cells without viral vectors.Human induced pluripotent stem cells free of vector and transgene sequences.A more efficient method to generate integration-free human iPS cells.Virus-free induction of pluripotency and subsequent excision of reprogramming factors.piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells.Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon.Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome.Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells.Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds.Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2.Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds.Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes.Hypoxia enhances the generation of induced pluripotent stem cells.Immortalization eliminates a roadblock during cellular reprogramming into iPS cells.The Ink4/Arf locus is a barrier for iPS cell reprogramming.Suppression of induced pluripotent stem cell generation by the p53-p21 pathway.A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity.Linking the p53 tumour suppressor pathway to somatic cell reprogramming.Deterministic direct reprogramming of somatic cells to pluripotency.Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1.H1foo has a pivotal role in qualifying induced pluripotent stem cells.Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells.Epigenetic memory in induced pluripotent stem cells.Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells.Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells.Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells.Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells.A panel of CpG methylation sites distinguishes human embryonic stem cells and induced pluripotent stem cells.Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells.Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives.Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells.Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells.Epigenetic variation between human induced pluripotent stem cell lines is an indicator of differentiation capacity.Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts.Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes.Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells.Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population.Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts.Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells.Chemically defined generation of human cardiomyocytes.SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells.Efficient and scalable purification of cardiomyocytes from human embryonic and induced pluripotent stem cells by VCAM1 surface expression.NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes.Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes.Glutamine oxidation is indispensable for survival of human pluripotent stem cells.Efficient detection and purification of cell populations using synthetic microRNA switches.High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents.Electrophysiological and contractile function of cardiomyocytes derived from human embryonic stem cells.Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker.Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology.Engineering adolescence: maturation of human pluripotent stem cell-derived cardiomyocytes.Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype.Enhanced engraftment, proliferation, and therapeutic potential in heart using optimized human iPSC-derived cardiomyocytes.Tri-iodo-l-thyronine promotes the maturation of human cardiomyocytes-derived from induced pluripotent stem cells.Matrigel mattress: a method for the generation of single contracting human-induced pluripotent stem cell-derived cardiomyocytes.Ultrastructural maturation of human-induced pluripotent stem cell-derived cardiomyocytes in a long-term culture.Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes.Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes.Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes.Developmental expression of troponin I isoforms in fetal human heart.Acquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem cell-derived cardiac myocytes.Return to the fetal gene program: a suggested metabolic link to gene expression in the heart.Myosin heavy chain isoform expression in the failing and nonfailing human heart.Myosin types in the human heart.