2009 Sep;33(9):1293-8. doi: 10.1097/PAS.0b013e3181a3166d.Cao D, Allan RW, Cheng L, Peng Y, Guo CC, Dahiya N, Akhi S, Li J.Hum Pathol. Our study demonstrates that OCT4 is a highly specific and sensitive immunohistochemical marker for primary intracranial germinomas. 2018 Apr 4;13(4):e0194594. Germ cell neoplasia in situ, abbreviated GCNIS, is a premalignant lesion of the testis.. These embryonal carcinoma components were all positive for CD30 with staining of greater than 90% of the tumor cells but with variable staining intensity. 2005 Feb;18 Suppl 2:S61-79. We examined histologic sections from 25 cases of germinoma in which paraffin blocks with sufficient material were available. doi: 10.1097/PAS.0000000000001465.Gui H, Kolster RA, Palmer MB, Brooks JS, Zhang M, Husson MA.Curr Oncol.
4 Oct. 2018, doi:10.1038/s41598-018-33094-7Hochedlinger, Konrad et al. used conditional expression and repression in murine embryonic stem cells to determine requirements for Oct-4 in the maintenance of developmental potency.The transcription factors Oct-4, Sox2 and Nanog are part of a complex regulatory network with Oct-4 and Sox2 capable of directly regulating Nanog by binding to its promoter, and are essential for maintaining the self-renewing undifferentiated state of the inner cell mass of the blastocyst, Oct-4 is one of the transcription factors used to create Several studies suggest a role for Oct-4 in sustaining self-renewal capacity of Zeineddine, Dana et al.
All cases were reviewed and sections from 32 different blocks were obtained and immunostained for OCT4 and PLAP.
2005 Aug;174(2):569-70. doi: 10.1016/s0022-5347(01)68313-7.Zhonghua Bing Li Xue Za Zhi. We investigated: 1) whether a similar pattern of expression is present in primary intracranial germinomas; and 2) how OCT4 compares with placental alkaline phosphatase (PLAP) in terms of specificity and sensitivity as a potential diagnostic tool. eCollection 2018.Int J Clin Exp Pathol. J Obstet Gynaecol Res. Terms • Germ cells- – A germ cell is any biological cell that gives rise to the gametes of an organism that reproduces sexually.
2007 Jan;211(1):1-9. doi: 10.1002/path.2105.Int J Clin Exp Pathol.
2019 Sep 11;10:619. doi: 10.3389/fendo.2019.00619. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. OCT4 immunostaining has comparable sensitivity but greater consistency compared with CD30 in the diagnosis of embryonal carcinoma. OCT4 (POU5F1) is a transcription factor expressed in embryonic stem and germ cells and is involved in the regulation and maintenance of pluripotency. Outline • Introduction – Terms, basis, classification, stats • Primitive germ cell tumors • Teratomas – Mature – Immature • Mixed – Gonadoblastoma 3.
Diagnostic utility of CD117, CD133, SALL4, OCT4, TCL1 and glypican-3 in malignant germ cell tumors of the ovary. “The Oct4 protein: more than a magic stemness marker.” American journal of stem cells vol. Ki-1 (CD30) antigen is regularly expressed in tumor cells of embryonal carcinoma. Author information: (1)Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. Epub 2019 Oct 1.Gusev FE, Reshetov DA, Mitchell AC, Andreeva TV, Dincer A, Grigorenko AP, Fedonin G, Halene T, Aliseychik M, Goltsov AY, Solovyev V, Brizgalov L, Filippova E, Weng Z, Akbarian S, Rogaev EI.FASEB J.
2019 Oct;26(5):e707. In conclusion, both gliomatosis peritonei and glioma arising … In this study, immunohistochemical stains of germ cell markers, including SALL4, OCT3/4, glypican-3, and alpha-fetal protein (AFP), and CDX2 were performed in a series of MMMTs. doi: 10.1371/journal.pone.0194594. Wolters Kluwer We examined histologic sections from 91 primary testicular neoplasms, including 64 cases of mixed germ cell tumors containing embryonal carcinoma (54), seminoma (51), yolk sac tumor (38), mature teratoma (31), immature teratoma (20), and choriocarcinoma (15). Wolters Kluwer OCT4 (POU5F1) is a transcription factor expressed in embryonic stem and germ cells and is involved in the regulation and maintenance of pluripotency. Page views in 2020 to date: 5,029. Adv Anat Pathol. Search our pages with your browser's search features or the Search box above. Comment in J Urol. CD Markers - CD117. Unable to load your delegates due to an error Fifteen of the 54 germ cell tumors containing embryonal carcinoma were also examined with antibodies to CD30. It has been detected in primary testicular germ cell tumors with pluripotent potential, seminoma, and embryonal carcinoma. SALL4 nuclear immunoreactivity was detected in 6 out of 19 cases … We undertook immunohistochemical staining of OCT4 in a wide variety of primary testicular neoplasms (germ cell tumors and other tumors) to assess the specificity and usefulness of this marker as a diagnostic tool. Click This is a free, no registration website - we are entirely supported by advertising. The intensity of OCT4 immunostaining was significantly better than that of PLAP. Hattab EM(1), Tu PH, Wilson JD, Cheng L. Author information: (1)Department of Pathology and Laboratory Medicine, Indiana University Medical Center, Indianapolis, IN 46202, USA. Table of Contents. Please enable it to take advantage of the complete set of features! In addition, we examined sections from spermatocytic seminomas (5), Leydig cell tumors (8), Sertoli cell tumors (6), unclassified sex-cord stromal tumors (4), adenomatoid tumors (2), testicular tumor of adrenogenital syndrome (1), and granulosa cell tumor (1). doi: 10.1097/00000478-200407000-00014. OCT4 has been detected in primary testicular germ cell tumors with pluripotent potential: seminoma and embryonal carcinoma. Name must be less than 100 characters OCT4: a sensitive and specific immunohistochemical marker for metastatic germ cell tumors.
Embryonal Carcinoma. Our mission is to provide useful professional information to practicing pathologists and laboratory personnel, through our textbook, in 15 seconds or less.