Cellular and Molecular Biosciences Currently, Dr. Sato explores the effect of glucocorticoid signal to clock system and epigenetic mechanisms.Dr. Dr. Sassone-Corsi's major interest is concentrated on the mechanisms of signal transduction able to modulate nuclear functions and, in particular gene expression, chromatin remodeling and epigenetic control. Relevant Publications: A., & Sassone-Corsi, P. (2018) Human metabolomics reveal daily variations under nutritional challenges specific to serum and skeletal muscle.
Together, they both played ice hockey and wanted to maximize their potential for sports.
567(7749):464-465 PMID: 30911154
Cell.
Sato, S., Parr, E. B., Devlin, B. L., Hawley, J. Marlene is a current F31 NRSA Predoctoral Fellow and a former American Heart Association Predoctoral Fellow. Kinouchi, L., Magnan, C., Ceglia, N., Liu, Y., Cervantes, M., Pastore, N., Huynh, T., Ballabio, A., Baldi, P., Masri, S., Sassone-Corsi, P. (2018) Fasting imparts a switch to alternative daily pathways in liver and muscle. PMID: 30566858 In parallel, Dr. Smith is exploring how long-range signaling from the gut microbiome acts to influence host circadian physiology, focusing on brain metabolism. B., Robles, M. S., Roenneberg, T., Rosbash, M., Ruben, M. D., Rund, S., Sancar, A., Sassone-Corsi, P., Sehgal, A., Sherrill-Mix, S., Skene, D. J., Storch, K. F., Takahashi, J. S., Ueda, H. R., Wang, H., Weitz, C., Westermark, P. O., Wijnen, H., Xu, Y., Wu, G., Yoo, S. H., Young, M., Zhang, E. E., Zielinski, T., Hogenesch, J. Ceglia, N., Liu, Y., Chen, S., Agostinelli, F., Eckel-Mahan, K., Sassone-Corsi, P., Baldi, P. (2018) CircadiOmics: Circadan omic web portal. Kwapis, JL., Alaghband, Y., Kramar, E.A., Lopez, A.J., Vogel Ciernia, A., White, A.O., Shu, G., Rhee, D., Michael, C.M., Montellier, E., Liu, Y., Magnan, C.N., Chen, S., Sassone-Corsi, P., Baldi, P., Matheos, D.P., Wood, M.A. His current and future research interest is the application of the circadian clock in health and diseases. PMID: 30523327 B., Asher, G., Baldi, P., de Bekker, C., Bell-Pedersen, D., Blau, J., Brown, S., Ceriani, M. F., Chen, Z., Chiu, J. C., Cox, J., Crowell, A. M., DeBruyne, J. P., Dijk, D. J., DiTacchio, L., Doyle, F. J., Duffield, G. E., Dunlap, J. C., Eckel-Mahan, K., Esser, K. A., FitzGerald, G. A., Forger, D. B., Francey, L. J., Fu, Y. H., Gachon, F., Gatfield, D., de Goede, P., Golden, S. S., Green, C., Harer, J., Harmer, S., Haspel, J., Hastings, M. H., Herzel, H., Herzog, E. D., Hoffmann, C., Hong, C., Hughey, J. J., Hurley, J. M., de la Iglesia, H. O., Johnson, C., Kay, S. A., Koike, N., Kornacker, K., Kramer, A., Lamia, K., Leise, T., Lewis, S. A., Li, J., Li, X., Liu, A. C., Loros, J. J., Martino, T. A., Menet, J. S., Merrow, M., Millar, A. J., Mockler, T., Naef, F., Nagoshi, E., Nitabach, M. N., Olmedo, M., Nusinow, D. A., Ptácek, L. J., Rand, D., Reddy, A.
28(5):368-379. Cell, 174, 1571-1585.e11. Paolo Sassone-Corsi soutient sa thèse de biologie moléculaire à l' université de Naples en 1979 puis fait un premier post-doctorat dans le laboratoire de Pierre Chambon à Strasbourg, et un second au Salk Institute dans le laboratoire d' Inder Verma à San Diego en Californie.
(2019) Nutrient-sensitive transcription factors TFEB and TFE3 couple autophagy and metabolism to the peripheral clock. PMID: 28802040
His current and future research interest is the application of the circadian clock in health and diseases. (2017) Guidelines for genome-scale analysis of biological rhythms. The idea of a career in the national hockey league has long since faded, however, Dr. Koronowski’s interest in nutrition and metabolism has stuck with him. Dr. Petrus is fascinated by the ability of living organisms to adapt to changes in the environment, as he finds it very intriguing that this occurs over the day, every day. 1977 - Philips European Award for Young Investigators B. PMID: 29038112 (2017) Aged stem cells reprogram their daily rhythmic functions to adapt to stress. Cell Rep.. 27(8)2385-2398. In particular, he is interested in the role of the skeletal muscle clock and how this can be influenced by diet and exercise. The stimulation of intracellular pathways and the activation of specific protein kinases lead to transcriptional regulation by changes in the phosphorylation state of nuclear factors.
Dr. Koronowski is enthralled by the mechanisms through which environmental cues and dietary interventions regulate the epigenome and impact human health/disease. Cell Metabolism. Tognini, P., Murakami, M., Sassone-Corsi, P. (2018) Interplay between microbes and the circadian clock. Journal of Biological Rhythms. After spending a few years as a technician in the lab, Marlene became fascinated with research, so much so that she is now a Ph.D. student.
He is responsible for managing the daily operations of the lab and making sure the lab runs as smoothly as possible. Pastore, N., Vainshtein, A., Herz, N.J., Huynh, T., Brunetti, L., Klisch, T.J., Mutarelli, M., Annunziata, P., Kinouchi, K., Brunetti-Pierri, N., Sassone-Corsi, P., Ballabio, A. During her off time, Shoko loves seeing beautiful nature from the passenger’s seat of the car driven by her husband. Our hearts go out to his wife, Emiliana Borelli, PhD. Most of his hobbies are indoor, but he has tried to learn fishing recently. Cervantes, M., Sassone-Corsi, P. (2019) Modification of histone proteins by serotonin in the nucleus.